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INTEGRIN ALPHA6BETA4
Descriptors Found:
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DeCS
Descriptor
English
:
Integrin alpha6beta4
Descriptor
Spanish
:
Integrina alfa6beta4
Descriptor
Portuguese
:
Integrina alfa6beta4
Tree Number:
D12.776.543.750.705.408.460.170
D12.776.543.750.705.876.750
Definition
English
:
This intrgrin is a key component of
HEMIDESMOSOMES
and is required for their formation and
maintenance
in
epithelial cells
.
Integrin alpha6beta4
is also found on
thymocytes
,
fibroblasts
, and
Schwann cells
, where it functions as a
laminin
receptor (RECEPTORS,
LAMININ
) and is involved in
wound healing
, cell
migration
, and tumor invasiveness.
History Note
English
:
2003; use INTEGRIN ALPHA6BETA4 (NM) 1988-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
37497
Unique Identifier:
D039161
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS